OptiStem began work in March 2009. We will post details of publications arising from our research on this page.

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Title Citation Authors Publication Date
Injectable PEG-fibrinogen hydrogel adjuvant improves survival and differentiation of transplanted mesoangioblasts in acute and chronic skeletal muscle degeneration Skeletal muscle. Nov 26;2(1):24 Fuoco C, Salvatori ML, Biondo A,... 28/01/2014
Methods for Characterization-Manipulation of Human Corneal Cells and their applications in Regenerative Medicine Methods Mol Biol. 2012;916:357-72 Corradini F., Venturi B., Pellegrini G... 25/08/2013
Cell-autonomous Notch activity maintains the temporal specification potential of Development. 2012 Dec;139(24):4536-48 Mourikis P, Gopalakrishnan S,... 07/11/2012
Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting. Cancer Cell. 2012 Oct 16;22(4):479-93 Di Piazza M, Nowell CS, Koch U, Durham... 20/10/2012
Quantitative muscle strength assessment in Duchenne Muscular Dystrophy: longitudinal study and correlation with functional measures BMC Neurol. 2012 Sep 13;12:91 Lerario A, Bonfiglio S, Sormani MP,... 05/09/2012
Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle EMBO Mol Med. 2012 Sep;4(9):910-23. doi: 10.1002/emmm.201101075. Epub 2012 Aug 23. Didier N, Hourdé C, Amthor H, Marazzi G... 01/09/2012
Stem cell therapies for muscle disorders Curr. Op. Neurol. 25:597-603 Tedesco FS, Cossu G 25/08/2012
Comparative expression profiling identifies differential roles for Myogenin and J Mol Cell Biol. 2012 Dec;4(6):386-97 Liu QC, Zha XH, Faralli H, Yin H, Louis... 30/07/2012
Muscle satellite cells are primed for myogenesis but maintain quiescence with Cell Stem Cell. 2012 Jul 6;11(1):118-26 Crist CG, Montarras D, Buckingham M 10/07/2012
Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy. Sci Transl Med. 2012 Jun 27;4(140):140ra89 Tedesco FS, Gerli MF, Perani L,... 30/06/2012
Skeletal muscle stem cells adopt a dormant state post mortem and retain regenerative capacity Nat Commun. 2012 Jun 12;3:903 Latil M, Rocheteau P, Châtre L, Sanulli... 14/06/2012
Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrixassociated fibrin-driven inflammation coupled to the aMb2 leukocyte integrin receptor. Hum Mol Genet. 2012 May 1;21(9):1989-2004. Epub 2012 Mar 1. Vidal B, Ardite E, Suelves M, Ruiz-... 01/05/2012
An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming PLoS Genet. 2012 Apr;8(4):e1002605. Epub 2012 Apr 12. Radford EJ, Isganaitis E, Jimenez-... 12/04/2012
'Hearts and bones': the ups and downs of 'plasticity' in stem cell biology EMBO Mol Med. 2012 May;4(5):353-61 Bonfanti P, Barrandon Y, Cossu G 02/03/2012
Overlapping and divergent signalling pathways of N- and VE-cadherin in endothelial cells. Blood. 2012 Mar 1;119(9):2159-70. Epub 2012 Jan 12. Giampietro C, Taddei A, Corada M, Sarra... 01/03/2012
Haploinsufficiency of Myf5 reveals distinct cell fate potentials for adult skeletal muscle stem cells J Cell Sci. 2012 Apr 1;125(Pt 7):1738-49 Gayraud-Morel B, Chrétien F, Jory A,... 01/03/2012
Noggin recruits mesoderm progenitors from the dorsal aorta to a skeletal myogenic fate Dev Biol. 2012 May 1;365(1):91-100 Ugarte G, Cappellari O, Perani L,... 18/02/2012
Nitric oxide sustains long-term skeletal muscle regeneration by regulating fate of satellite cells via signaling pathways requiring Vangl2 and cyclic GMP. Stem Cells. 2012 Feb;30(2):197-209. doi: 10.1002/stem.783. Buono R, Vantaggiato C, Pisa V, Azzoni... 01/02/2012
Nitric oxide donor and non steroidal anti inflammatory drugs as a therapy for muscular dystrophies: evidence from a safety study with pilot efficacy measures in adult dystrophic patients Pharmacol Res. 2012 Apr;65(4):472-9. Epub 2012 Jan 25. D'Angelo MG, Gandossini S,... 25/01/2012
A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell division Cell. 2012 Jan 20;148(1-2):112-25 Rocheteau P, Gayraud-Morel B, Siegl-... 24/01/2012
PAI-1-regulated miR- 21 defines a novel age-associated fibrogenic pathway in muscular dystrophy. J Cell Biol. 2012 Jan 9;196(1):163-75. Epub 2012 Jan 2. Ardite E, Perdiguero E, Vidal B,... 09/01/2012
Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and –negative cells in vitro and in vivo J Invest Dermatol. 2012 Apr;132(4):1084-93 Driskell RR, Juneja VR, Connelly JT,... 22/12/2011
Characterization of Pax3 expressing cells from adult blood vessels. J. Cell Science J Cell Sci. 2011 Dec 1;124(Pt 23):3980-8. Epub 2011 Dec 8. Goupille O, Pallafacchina G, Relaix F,... 08/12/2011
A critical requirement for Notch signaling in maintenance of the quiescent skeletal muscle stem cell state Stem Cells. 2012 Feb;30(2):243-52 Mourikis P, Sambasivan R, Castel D,... 10/11/2011
Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence PLoS Genet. 2011 Nov;7(11):e1002348. Epub 2011 Nov 3. Nowell CS, Bredenkamp N, Tetélin S, Jin... 01/11/2011
p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair J Cell Biol. 2011 Oct 17;195(2):307-22. Epub 2011 Oct 10. Perdiguero E, Sousa-Victor P, Ruiz-... 17/10/2011
Pericytes resident in post-natal skeletal muscle differentiate into muscle fibers and enter the satellite cell pool Nat Commun. 2011 Oct 11;2:499. doi: 10.1038/ncomms1508. Dellavalle A, Maroli G, Covarello D,... 11/10/2011
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration Development. 2011 Sep;138(17):3647-56. Sambasivan R, Yao R, Kissenpfennig A,... 01/09/2011
Stem Cell-Mediated Transfer of a Human Artificial Chromosome Ameliorates Muscular Dystrophy Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy. Tedesco FS, Hoshiya H, D'Antona G... 17/08/2011
Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression. PLoS One. 2011;6(6):e21242. Epub 2011 Jun 17. Murakami M, Giampietro C, Giannotta M,... 17/07/2011
PW1 gene/paternally expressed gene 3 (PW1/Peg3) identifies multiple adult stem and progenitor cell populations Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11470-5. Epub 2011 Jun 27. Besson V, Smeriglio P, Wegener A,... 12/07/2011
PW1 gene/paternally expressed gene 3 (PW1/Peg3) identifies multiple adult stem and progenitor cell populations Proc Natl Acad Sci U S A. 2011 Jun 27. [Epub ahead of print] Besson V, Smeriglio P, Wegener A,... 27/06/2011
An eye on the head: the development and evolution of craniofacial muscles Development. 2011 Jun;138(12):2401-15. Sambasivan R, Kuratani S, Tajbakhsh S 01/06/2011
Structure and function of the thymic microenvironment Front Biosci. 2011 Jun 1;16:2461-77. Manley NR, Richie ER, Blackburn CC,... 01/06/2011
Moving to tolerance: clinical application of T regulatory cells Semin Immunol. 2011 Aug;23(4):304-13. Epub 2011 May 28. McMurchy AN, Bushell A, Levings MK,... 28/05/2011
Cellular and molecular mechanisms regulating fibrosis in skeletal muscle repair and disease Curr Top Dev Biol. 2011;96:167-201. Serrano AL Mann CJ Vidal B Ardite E... 26/05/2011
Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection. Sci Transl Med. 2011 May 18;3(83):83ra40. Feng G, Nadig SN, Bäckdahl L, Beck S,... 18/05/2011
A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy Pharmacol Res. 2011 Sep;64(3):210-7. Epub 2011 May 12. Sciorati C, Miglietta D, Buono R, Pisa... 12/05/2011
Aberrant repair and fibrosis development in skeletal muscle. Skelet Muscle. 2011 May 4;1(1):21. Mann CJ, Perdiguero E, Kharraz Y,... 04/05/2011
Regulation of skeletal muscle stem cells through epigenetic mechanisms. Toxicol Mech Methods. 2011 May;21(4):334-42. Sousa-Victor P, Muñoz-Cánoves P,... 01/05/2011
Lack of in vivo functional compensation between Pax family groups II and III in rodents Mol Biol Evol. 2011 Oct;28(10):2787-98. Epub 2011 Apr 21. Hayashi S, Rocancourt D, Buckingham M,... 21/04/2011
Adhesion molecule signalling: not always a sticky business. Nat Rev Mol Cell Biol. 2011 Mar;12(3):189-97. Cavallaro U, Dejana E. 01/03/2011
Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells. Eur J Immunol. 2011 Mar;41(3):726-38. doi: 10.1002/eji.201040509. Epub 2011 Jan 17. Francis RS, Feng G, Tha-In T, Lyons IS... 17/01/2011
Human embryonic stem-cell derived keratinocytes: how close to clinics? Cell Stem Cell, Volume 6, Issue 1, 8-9 Pellegrini G and De Luca M 08/01/2011
An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis EMBO Reports, 7 January 2011 [Epub ahead of print] Innocenzi A, Latella L, Messina G,... 07/01/2011
Cellular and molecular mechanisms regulating fibrosis in skeletal muscle repair and disease Curr Top Dev Biol. 2011;96:167-201. Serrano AL, Mann CJ, Vidal B, Ardite E... 01/01/2011
Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo BMC Genomics. 2010 Dec 8;11:696. Lagha M, Sato T, Regnault B, Cumano A,... 28/12/2010
News from the brain: the GPR124orphan receptors directs brain-specific angiogenesis Sci Transl Med. 2(58):58ps53 Dejana E, Nyqvist D 17/11/2010
Vision from the right stem Trends Mol Med. 2010 Nov 11. [Epub ahead of print] Pellegrini G, Rama P, De Luca M 11/11/2010
Megarole for microRNA in muscle disease Cell Metab. ;12(5):425-6. Crist, CG, Buckingham, M 03/11/2010
Direct effects of the pathogenic mutation on satellite cell function in muscular dystrophy Exp Cell Res 316, 3100-3108 (2010) Morgan, JE and Zammit, PS 01/11/2010
The role of wnt signaling in physiological and pathological angiogenesis Circ Res. 107(8):943-52 Dejana E 15/10/2010
Mesenchymal stromal cells: Facilitators of successful transplantation? Cell Stem Cell 7(4):431-42 English K, French A, Wood KJ 08/10/2010
The prolyl isomerase pin1 is involved in terminal differentiation and myocyte enhancer factor 2C function in skeletal muscle cells J. Biol. Chem. Nov 5; 285(45):34518-27 [Epub 2010 Aug 27] Magli A, Angelelli C, Ganassi M,... 27/08/2010
Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells Nature, 466, 978–982 (19 August 2010) Bonfanti P, Claudinot S, Amici AW,... 19/08/2010
Use of magnetically oriented orthogonal collagen scaffolds for hemi-corneal reconstruction and regeneration Biomaterials, 2010 Nov;31(32):8313-22 [Epub 2010 Aug 13] Builles N, Janin-Manificat H,... 13/08/2010
Stem cell therapies to treat muscular dystrophy: progress to date BioDrugs, 24(4):237-47 Meregalli M, Farini A, Parolini D,... 01/08/2010
Evaluation of molecular markers in corneal regeneration by means of autologous cultures of limbal cells and keratoplasty Cornea. 2010 Jul;29(7):715-22. Colabelli Gisoldi RA, Pocobelli A,... 01/07/2010
Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration N Engl J Med, 2010, 363:147-55 Rama P, Matuska S, Paganoni G, Spinelli... 23/06/2010
The Wnt/b-catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling Dev Cell. 18(6):938-49 Corada M, Nyqvist D, Orsenigo F,... 15/06/2010
Characteristics of the early immune response following transplantation of mouse ES cell derived insulin-producing cell clusters PLoS One, 5(6): e10965 Boyd AS, Wood KJ 04/06/2010
Regulation and dysregulation of fibrosis in skeletal muscle Exp Cell Res. 2010 Nov 1;316(18):3050-8. [Epub 2010 Jun 4] Serrano AL, Munoz P 04/06/2010
Combining Stem Cells and Exon Skipping Strategy to Treat Muscular Dystrophy Chapter 15, Muscle gene therapy (Ed. Dongsheny Duan), Springer Meregalli M, Farini A, Torrente Y 01/06/2010
Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation Cell Death Differ. 2010 Nov;17(11):1684-96. [Epub 2010 May 14] De Palma C, Falcone S, Pisoni S,... 14/05/2010
Co-administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans Br. J. Pharmacol. 160: 1550-1560, 2010 C. Sciorati, R. Buono, E. Azzoni, S.... 22/04/2010
A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis PLoS Genetics, 6(4):e1000897 Sato T, Rocancourt D, Marques L,... 01/04/2010
CCM1 regulates vascular-lumen organization by inducing endothelial polarity J Cell Sci. 123(Pt 7):1073-80 Lampugnani MG, Orsenigo F, Rudini N,... 01/04/2010
Nfix Regulates Fetal-Specific Transcription in Developing Skeletal Muscle Cell, Volume 140, Issue 4, 554-566 Messina G, Biressi S, Monteverde S,... 19/02/2010
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin PLoS ONE 5(2): e9258 Dumortier A, Durham A, Di Piazza M,... 18/02/2010
Inactivation of junctional adhesion molecule-A enhance antitumoral immune response by promoting dendritic cell and T lymphocyte infiltration Cancer Res. 2010 Mar 1;70(5):1759-65 [Epub 2010 Feb 16] Murakami M, Francavilla C, Torselli I,... 16/02/2010
Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development Nat Cell Biol. 2010, 12(3):257-266 [Epub 2010 Jan 31] Mitchell KJ, Pannerec A, Cadot B,... 31/01/2010
Identification and characterisation of a non-satellite cell resident muscle progenitor during postnatal development Nature Cell Biology 12, 257 - 266 (2010) Mitchell KJ, Pannérec A, Cadot B,... 31/01/2010
Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells J. Clin. Invest. 120(1): 11-19 Tedesco FS, Dellavalle A, Diaz-Manera J... 04/01/2010
Pax3:Foxc2 Reciprocal Repression in the Somite Modulates Muscular versus Vascular Cell Fate Choice in Multipotent Progenitors Dev. Cell, 17, 892-899 Lagha M, Brunelli S, Messina G, Kume T... 15/12/2009
An adult tissue-specific stem cell in its niche: a gene profiling analysis of in vivo quiescent and activated muscle satellite cells Stem Cell Res. Oct 28. [Epub ahead of print]. Pallafacchina G, François S, Regnault B... 28/10/2009
Muscle stem cell behaviour is modified by microRNA-27 regulation of Pax3 expression Proc. Natl. Acad. Sci. USA, 106, 13383-13387 Crist CG, Rocancourt D, Montarras D and... 28/07/2009
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis Development 136, 2815-2823 Driskell RR, Giangreco A, Jensen KB,... 15/07/2009
Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9 Diabetes, 58(8):1797-806 Ding Y, Xu D, Feng G, Bushell A,... 09/06/2009
Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos PLoS One., 3;4(6):e5772 Montero-Balaguer M, Swirsding K,... 03/06/2009
Challenges in translational research EMBO Mol. Med. 1, 79-80 Cossu G 08/05/2009
Nerve growth factor promotes in vitro human conjunctival epithelial cells differentiation and mucin gene expression Invest. Ophthalmol. Vis. Sci. 50:4622-4630 Lambiase A, Micera A, Pellegrini G,... 30/04/2009
Gene therapy of inherited skin adhesion disorders: a critical overview Br. J. Dermatol. 161(1):19-24 De Luca M, Pellegrini G and Mavilio F 20/04/2009
The origin of embryonic and fetal myoblasts: a role of Pax3 and Pax7 Genes & Dev. 23, 902-905 Messina G and Cossu G 15/04/2009
The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications Dev Cell.,16(2):209-221 Dejana E, Tournier-Lasserve E,... 17/02/2009
Skeletal muscle differentiation of embryonic mesoangioblasts requires Pax3 activity Stem Cells, 27, 157-164 Messina G, Sirabella D, Monteverde S,... 05/01/2009
Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees Cell Tissue Res., 335(1):17-25 Dejana E, Orsenigo F, Molendini C,... 01/01/2009
JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling J Cell Sci., 122(Pt 2):268-77 Cera MR, Fabbri M, Molendini C, Corada... 31/12/2008
Isolation and production of cells suitable for human therapy: challenges ahead Cell Stem Cell 4(1):20-26 Ahrlund-Richter L, De Luca M, Marshak... 04/12/2008
Epithelial stem cells in corneal regeneration and epidermal gene therapy J. Pathol. 217:217-228 Pellegrini G, Rama P, Mavilio F and De... 11/09/2008