Clinical applications

Fibrin substratum prepared from a surgical glue. From Ronfard et al., TRANSPLANTATION 2000Fibrin substratum prepared from a surgical glue. From Ronfard et al., TRANSPLANTATION 2000Stem cells have great potential for treating disease. In fact, skin stem cells have already been used for over 25 years to grow skin grafts for patients with extensive burns. However, problems still exist with these skin grafts, and we have a lot to learn before other types of stem cells can be used routinely in medicine.

OptiStem aims to pave the way for new stem cell therapies through a combination of basic stem cell biology, pre-clinical work and clinical trials.

Our clinical work focuses on potential treatment strategies for:


Information for patients

Due to the experimental nature of these studies we cannot at the moment offer treatments; opportunities to participate in clinical trials will become available on the website at appropriate times. This website provides scientific information about our clinical research. If you are looking for general information on stem cells and their potential use in treating disease, please visit the Frequently Asked Questions section of


Pre-clinical work

Our pre-clinical work bridges the gap between fundamental stem cell biology and clinical trials. This part of our work includes:

These investigations will allow us to optimize our protocols while progressing to clinical trials.

Clinical trials

We will carry out a number of early-stage (Phase I/IIa) clinical trials:

Clinical trials will begin in 2010. More information will be posted here as the trials progress.


Clinical Trials Update: May 2012

Trial A - Duchenne muscular dystrophy: Transplantation of pediatric patients with mesoangioblasts from healthy donors started in March 2011 and the three first patients have been treated. Results are being analyzed. Two more will be treated in the autumn of 2012.

Trial B - Duchenne muscular dystrophy: Transplantation of patients with CD133+ cells (genetically corrected stem cells from their own bodies) is planned to start at the end of 2012 or at beginning of 2013.